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OSAKAI, Toshiyuki (Associate Professor)

大堺 利行 准教授

Specialized Field
Solution Chemistry
Research Interests

The oil/water (O/W) interface is the simplest model of a biomembrane, being fundamentally important for understanding energy conversions (i.e., respiratory and photosynthetic electron transport systems) and also nerve transmission in biological systems. In our laboratory, mechanistic studies are performed on charge (ion or electron) transfers across the oil/water interface, the potential difference of which is controlled electrochemically. As the analytical applications, electrochemical sensing systems are developed for biological substances such as proteins. In addition, cooperative studies with other universities and companies are being carried out for electrolytic chromatography, copper corrosion, anticancer drugs, etc.

Research Subjects
  • Label-free electrochemical detection of proteins with the O/W interface
  • Potential-Modulated Fluorescence (PMF) spectroscopy for adsorptive compounds at the O/W interface
  • Kinetics of the electron transfer at the O/W interface
  • Amperometric ion sensors with the O/W interface
  • Novel electrolytic chromatography
  • Electrochemical studies on copper corrosion
Selected Publications

◆Potential-Dependent Adsorption of Amphoteric Rhodamine Dyes at the Oil/Water Interface as Studied by Potential-Modulated Fluorescence Spectroscopy, T. Osakai, H. Yamada, H. Nagatani, and T. Sagara, J. Phys. Chem. C, 111, 9480-9487 (2007).

◆Which Is Easier to Reduce, Cu2O or CuO?, S. Nakayama, T. Kaji, M. Shibata, T. Notoya, and T. Osakai, J. Electrochem. Soc., 154, C1-C6 (2007).

◆Electrochemical Extraction of Proteins by Reverse Micelle Formation, M. Shinshi, T. Sugihara, T. Osakai, and M. Goto, Langmuir, 22, 5937-5944 (2006).

◆Clarification of the Mechanism of the Interfacial Electron-Transfer Reaction between Ferrocene and Hexacyanoferrate(III) by Digital Simulation of Cyclic Voltammograms, H. Hotta, S. Ichikawa, T. Sugihara, and T. Osakai, J. Phys. Chem. B, 107, 9717-9725 (2003).

◆Complete Electrolysis Using a Microflow Cell with an Oil/Water Interface, S. Sawada, M. Taguma, T. Kimoto, H. Hotta, and T. Osakai, Anal. Chem., 74, 1177-1181 (2002).

◆Unusually Large Numbers of Electrons for the Oxidation of Polyphenolic Antioxidants, H. Hotta, H. Sakamoto, S. Nagano, T. Osakai, and Y. Tsujino, Biochim. Biophys. Acta, 1526, 159-167 (2001).

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